PAT 20A/B Chapter N/A: (2)PAT20 Fall Week 6 Drug Classifications (Stroke)

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Stroke: anti-coagulant, coumarins (antidote: vitamin k) *coagulation modifying agent* (anti- clot factor) Action: works in the liver to inhibit vitamin k-dependent clotting factors 2, 7, 9, 10. Anorexia, nausea, vomiting, alopecia (long-term use), dermatitis, fever, urticarial, tissue necrosis or gangrene, agranulocytosis. Tablets = 1-2. 5, 3- 6, 7. 5, 10 mg; injection (iv) = 50 mg/vial. Lab test evaluation: inr: direct thrombin inhibitor *coagulation modifying agent* (anti- blood clot) Direct thrombin inhibitor drugs: dabigantran etexilate (pradaxa*), argatroban (argatroban), clopidogrel (plavix) Action: binds directly to thrombin to prevent platelets in your blood from sticking together and forming a blood clot. Lab test evaluation: ptt: low molecular weight heparin parin *coagulation modifying agent* (anti- thrombi) (antidote: protamine) Low molecular weight heparin drugs: dalteparin sodium (fragmin), enoxaparin (lovenox), tinzaparin (innohep) Action: works circulating clotting factors to accelerate formation of an antithrombin. 3-thrombin complex, inactivate thrombin and prevent conversion of fibrinogen to fibrin.

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