BPK 142 Chapter Notes -Bone, Bone Marrow, Extracellular Matrix

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Bone is a tissue composed of living cells (osteocytes) distributed in an intercellular matrix that contains organic and inorganic substances. The organic component, largely collagenous fibres, is responsible for the strength and resilience of bone while the inorganic salts, mostly calcium phosphate, contribute to its hardness, and rigidity. The inorganic constituents make up approximately 67% of bony matter in the adult: forms of bone tissue. There are two forms of bone tissue, cancellous and compact. Cancellous or spongy bone consists of irregular strands of tissue, which branch and joins one another, forming a loose network in which the intercommunicating spaces are filled with marrow. Compact or dense bone has a more solid, regular appearance and its intercommunicating canals are microscopic in size. The basic structure of these two types of bone is essentially the same. They differ mainly in the relative amount of solid substance and the number, size, and arrangement of the intercommunicating spaces they contain.

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