BPK 205 Chapter Notes -Pulmonary Stretch Receptors, Peripheral Chemoreceptors, Local Anesthetic
SchoolSimon Fraser University
DepartmentBiomedical Physio & Kines
Course CodeBPK 205
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34. Compare and contrast the stimuli and rate of response of central and
oStimuli: CO2 increase in Cerebrospinal fluid
oRate of response: within 1 min of stimulus
oStimuli: PaCO2 increase, PaO2 decrease, pH decrease, increase all
detected in the carotid bodies, and aortic arch
oRate of response: within 2-3 breaths
35. Describe the Hering-Breuer inflation reflex.
•Inspiration causes increased air flow, and blood flow into pulmonary
vessels. This stretches pulmonary stretch receptors, inducing the Hering-
Breuer reflex. The reflex causes inhibition of inspiration, so that the
expiration phase can be commenced. It also increases breathing
frequency by shortening expiration phase too.
36. Compare and contrast the O2 and CO2 effects on ventilation.
37. From an acid-base perspective, what 2 factors is pH dependent upon and
•Ventilation rate (lungs, CO2 levels), and Metabolic factor (kidneys, HCO3-
•CO2 + H2O H2CO3 H+ + HCO3-
•Increased CO2 shifts equation right to produce more H+ and lower pH
•Increased HCO3- shifts it left to reduce H+ and raise pH
38. Describe in terms of speed and capacity only, the 3 systems that
compensate acid-base disturbances.
oECF: Bicarbonate and Hb buffer, ICF: proteins, phosphates
oCapacity: most limited
oIncrease/decrease ventilation; VCO2rate
oIncrease/decrease HCO2- excretion
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