Creates intense feelings of pleasure, increases alertness & decreases appetite and need for sleep. Coca use traced to inca empire in peru 5000 bce. Andes mountains" natives still use coca today. Calcified lime can be added to coca to increase extraction of cocaine, allowing greater absorption into the blood supplying inside of the mouth. Erythroxylon coca thrive at elevations of 600-2400m on amazon slope of mountains. The spanish treated coca like money in trades. Mariani introduced coca leaf indirectly to the public. He imported coca leaves and used an extract from them in many products. Coca wine made him rich and famous. Extraction of coca leaf lifted spirits, relieved fatigue & gave a good feeling. Later, cocaine was also used in dentistry. Early psychiatric use - sigmund freud (viennese physician) Studied cocaine for its potential as a treatment medication for ailments including depression, morphine dependence and more. Praised the drug as a safe exhilarant.