PSYC 365 Chapter Notes -Upper Respiratory Tract Infection, Immunocompetence, Herpesviridae

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Psycho (psychology) affects ns functioning (neuro) which in turn affects immune function (immunology) Dv measured to see effect of manipulation, in pni the dv is immunocompetence. Iv is psychological state: hard b/c many sites of immune system, many varieties of cellular activity in immune system, counting cells to measure immunocompetence: Immune system function is dependent on system"s ability to produce/proliferate (cells to do its work: count cells (typically white blood cells) as they occur in bloodstream- Nk seek and detroy so activity measured by exposing them to disease (usually tumor) cells. After exposure nk cells assessed by either: proliferation measured thru cell counts after intro of antigen, effectiveness assessed thru measuring destruction of antigens (nk cell cytotoxic activity assay) Process of killing antigens (tumor cells) is nk cell lysis. Nk cells not the only ones capable of cytotoxic activity, commonly used in cancer studies: number of in vivo functional tests of immunocompetence.

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