Intermittent fasting in cardiovascular disorders an overview. Intermittent fasting is considered to be less restrictive compared to traditional methods of calorie restriction: there are two basic varieties of the intermittent fasting diet. There are two possible systems, 5:2 or 4:3. In an 18-hour fasting window, ketones remain increased. Impact of intermittent fasting on inflammatory biomarkers: 4 of 6 studies showed insignificant results in terms of changes in inflammatory biomarker levels with if. In this study, they included if and low calories together vs separate to compare effects (good!) It was observed that the cardiovascular health benefits do not last longer than the period of the if diet. After its completion, the pressure values return to their initial values. Initially, all animal were fed a high fat diet (45% fat) over a period of 8 weeks to obtain an obese phenotype.