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BIOL 1090 (72)
Chapter 12

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Department
Biology
Course
BIOL 1090
Professor
Marc Coppolino
Semester
Winter

Description
12.1 - The Nucleus of Eukaryotic Cell - Enclosed by a complex nuclear envelope that forms a boundary between the nucleus and the cytoplasm. - Composed of o Chromosomes o Nucleoli (synthesis of ribosomal RNA and the assembly of ribosomes) o Nucleoplasm - where the solutes of nucleus are dissolved o Nuclear matrix - protein-containing fibrillar network. Nuclear Envelope - Consists of two cellular membranes arranged parallel to one another. - Barrier that keeps ions, solutes and macromolecules from passing freely between the nucleus and cytoplasm. - 2 membranes fused at sites forming circular pores that contain complex assemblies of proteins. - Outer membrane generally studded with ribosomes and is continuous with the membrane of the rough ER. - Space between membranes is continuous with the ER lumen. Inner surface of the nuclear envelope is bound by integral proteins to a thin filamentous meshwork  nuclear lamina. o Provides mechanical support to the nuclear envelope. o Serves as site of attachment for chromatin fibers at the nuclear periphery. o Roles in DNA replication and transcription. o Composed of polypeptides called lamins. Nuclear Pore Complex (NPC)
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