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Canada (161,660)
MICR 3230 (19)
Chapter

Chp 8 Major Histocompatibility Complex/Antigen Presentation

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Department
Microbiology
Course
MICR 3230
Professor
Azad Kaushik
Semester
Fall

Description
The Major Histocompatibility Complex and Antigen Presentation (Chapter 8) Summary - MHC encodes class I, II molecules functioning in antigen presentation to T cells, class III molecules with diverse functions - MHC genes tightly linked and generally inherited as a “block” from parents  groups of alleles called haplotypes - MHC genes are polymorphic – many alleles exist for each genes – polygenic – many different genes exist - Class II molecules  large glycoprotein chain and β2-microglobulin, protein with a single domain - Class I molecules expressed on almost all nucleated cells - Class II molecules restricted to B cells, macrophages & dendritic cells * APC - Proteasomes and transporters involved in antigen processing (before T cell recognition) - MHC alleles influence immune responsiveness and antigen presenting ability  also susceptibility to many diseases + - Class I molecules  present endo
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