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Canada (161,562)
MICR 3230 (19)
Chapter

Chp10 T-Cell Maturation, Activation & Differentiation

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Department
Microbiology
Course
MICR 3230
Professor
Azad Kaushik
Semester
Fall

Description
T Cell Maturation, Activation & Differentiation (Chapter 10) Summary - progenitor T cells from bone marrow enter thymus and rearrange TCR genes - thymocytes rearrange αβ TCR genes to become αβT cells.. small percentage rearrange γδ to become γδ T cells - DN (double negative) cells lack CD4 and CD8 (early thymocytes) - During development, double negative thymocytes develop (expression of either CD4 or CD8) - Positive selection: eliminates T cells unable to recognize self MHC  MHC restriction - Negative selection: eliminate thymocytes bearing high affinity receptors for self MHC molecules (alone or self MHC plus self antigen)  self tolerance - T cell activation initiated by interaction of TCR-CD3 complex with a peptide- MHC complex on an APC - Activation requires accessory molecules including co-receptors CD4/CD8 - Intracellular signal transduction pathways activated by TCR engagement - T cells expressing CD4 recognize MHC-I
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