PSYC 2410 Chapter Notes - Chapter 5: Metabotropic Glutamate Receptor, Morris Water Navigation Task, Dentate Gyrus
1 Aug 2013
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Agonist: drug that facilitates effects of a neurotransmitter. Antagonist: drug that inhibits effects of a neurotransmitter. Competitive binding: direct agonist or antagonist, binds to same binding site as neurotransmitter, whoever gets their first , more drug you have (higher dosage), more likely it will bind over the neurotransmitter. Noncompetitive binding: bind to allosteric site on receptor, neuromodulators , can modulate conformation of the transmembrane protein. Too much can lead to cytotoxicity (over fire and die) 4 receptors: ndma, ampa, kainate (all ionotropic) and metabotropic glutamate receptor. Recycling glutamate either through eaat3 directly back into cell or sucked into nearby astrocyte via eaat1 or eaat2, converted to glutamine and then diffuses back into presynaptic neuron (glutamate shuttle) where both processes are repackaged by vglut. Ampa and kainate receptors are na+ channels, nmda is as well but has mg2+ ion blocking it at rest, membrane must be excited (to dislodge blocker) and glutamate must bind in order for channel to open.
