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Chapter

PSYC 3390 Chapter Notes -Risperidone, Senile Plaques, Retrograde Amnesia


Department
Psychology
Course Code
PSYC 3390
Professor
Mary Manson

Page:
of 8
Abnormal Psychology Week 10
Schizophrenia
-a significant loss of contact with reality, referred to as psychosis.
DSM-IV-TR Criteria-
2 or more of the following present for a significant portion of one month:
delusions,
hallucinations,
disorganized speech,
catatonic/grossly disorganized behaviour,
negative symptoms.
-only one symptom is needed if delusions are bizarre/hallucinations consist of a voice keeping a running commentary of person’s
behaviour/thoughts, or 2+voices conversing.
dysfunction in work, interpersonal relations or self-care
signs of disturbance for at least 6 months
Case Study: Emilio: 40 years old: looks 10 years younger: his mother is afraid of him- dresses in a ragged overcoat, slippers, ball cap and
medals around his neck. Affect ranges from anger at his mother to giggling. Childlike speech and manner. Walks with a mincing step and
exaggerated hip movements. Stopped taking meds 1 month ago and has since begun hearing voices and act more bizarre. Speech often
rhymes and is incoherent. Has been hospitalized 12 times, doesn’t take meds after leaving hospital. Dropped out of school at 16, hasn’t
been able to hold a job, lives with mom but often disappears for months at a time.
-schizophrenia is about as prevalent as epilepsy. Lifetime morbid risk = 1.0% (1 out of every 100 people who live to at least 55 will
develop schizophrenia)
-children whose fathers are older (45-50 years) at the time of their birth have 2-3 times the normal risk of developing schizophrenia
-people of Afro-Caribbean origin living in the UK have a higher rate
-rates are unusually high in western Ireland and Croatia, and especially low in Papua New Guinea.
-often begins in late adolescence, early childhood. Sometimes, but rarely found in children. Can also have initial onset at middle age, but
not typically.
-tends to begin earlier in men (peaks between 20-24 years), peaks at the same age for women, but peak is much lower. After 35, men
developing schizophrenia drops drastically, where women has a second increase that begins around 40 years.
-average age of onset: men- 25 years, women- 29 years
-males often develop more severe forms of schizophrenia.
-it is likely that schizophrenia is milder in women because of higher levels of estrogen (when estrogen levels are low/falling, psychotic
symptoms in women with schizophrenia often get worse). The protective effect of estrogen may then help the delayed onset of
schizophrenia in women. Declining levels of estrogen around menopause might explain the late-onset.
Origins
-first clinical description of schizophrenia- John Haslam at Bethlem Hospital in London. James Tilly Matthews was patient. Suffered
Delusions
-50 years later, Belgian psychiatrist Benedict Morel 13 year old boy who had been brilliant in school suddenly became withdrawn,
lethargic, reclusive and forgot everything he’d learned.- described it as demence precoce (mental deterioration at an early age)
-German psychiatrist emil kraepelin- best known for his description of schizophrenia. Used the term dementia praecox to refer to a
group of conditions that seemed to feature mental deterioration beginning early in life. described the patient as someone who “becomes
suspeicious of those around him, sees poison in his food, is pursued by the police, feels his body is being influenced, or thinks that he is
going to be shot or that the neighbours are jeering at him”- also noted that the disorder was characterized by hallucinations, apathy and
indifference, withdrawn behaviour and incapacity for regular work.
-Swiss Psychiatrist Eugen Bleuler used the term schizophrenia (schizien= German for split, phren = Greek meaning mind) meant it as
a jeckyll and hyde sort of thing
Delusions
-delusion= an erroneous belief that is fixed and firmly held despite clear contradictory evidence.
-comes from the latin verb ludere, meaning to play (ie tricks on the mind)
-disturbance in the content of thought (believe in things that others of similar background do not_
-ie false beliefs: people with delusions don’t always have schizophrenia
Hallucinations
-Hallucination: a sensory experience that occurs in the absence of any external perceptual stimulus.
-very different from an illusion (which is a misperception of an existing stimulus)
-occur in any sensory modality (5 senses)
-auditory hallucinations are the most common (75%)
-visual hallucinations are uncommon (less than 15%), tactile hallucinations even more rare.
-hallucinations often have relevance for the patient at an affective, conceptual or behavioural level (ie: Nayani and David (1996) studied
hallucinating patients 73% reported that the voices usually spke at conversational volume and were often voices of people known to the
patient in real life. Voices of God/Devil also sometimes heard.
-voices were often worse when alone and rude/vulgar, criticizing, bossy or abusive.
-some voices can be pleasant and supportive
-PET and fMRI scans show that patients with auditory hallucinations show increased activity in Broca’s area (involved in speech
production) rather than the auditory Wernicke’s area) similar patterns to normal people asked to imagine someone talking to them
-research suggests that auditory hallucinations occur when patients misinterpret their own self-talk/inner speech
Disorganized Speech
-disorganized speech is the external manifestation of a disorder in thought form.
-an affected person fails to make sense, despite seeming to conform to the semantic and syntactic rules of communication.
-Meehl described it as “cognitive slippage” (incoherence)
-words and combinations sound communicative, but in fact they make no sense. In some cases, completely new words (neologisms)
appear in the patient’s speech. (ie: detone)
Disorganized and Catatonic hehaviour
-disorganized behaviour is an impairment of routine daily functioning such as work, relations and self-care (ie dressing in unusual
manner- scarf/parka on a hot day)
-Catatonia- patient may show absence of all movement and speech (called a catatonic stupor). At other times, the patient may hold an
unusual posture for an extended period of time without discomfort.
Negative symptoms
-positive symptoms are those that reflect an excess or distortion in a normal repertoire of behaviour and experience (ie
delusions/hallucinations
-negative symptoms reflect an absence or deficit of behaviours that are normally present (ie flat emotion, little speech, avolition (no ability
to initiate goal-directed activities)
-a preponderance of neg symptoms is not a good sign for the patient’s future outcome.
Subtypes of Schizophrenia
Paranoid shows a history of increasing suspiciousness and of severe difficulties in interpersonal relationships. persecutory delusions
are more frequent. Delusions of grandeur are also common as an explanation to why they are being persecuted, followed or spied on.
-DSM: preoccupation with delusions/frequent auditory hallucinations; no evidence of marked disorganized speech, disorganized
catatonic behaviour or inappropriate affect.
Disorganized- usually occurs at an earlier age and has a gradual, insidious onset.
DSM characterized by disorganized speech, disorganized behaviour, flat or inappropriate affect, no evidence of catatonic
schizophrenia. : ie case study Emilio
-hallucinations/delusions may be present, but not formed into a meaningful story like paranoid
Catatonic- central feature is pronounced motor signs, either of an excited or stuporous type. Highly suggestible and will obey
commands/imitate actions of others (echopraxia) or mimic phrases (echolalia.
-DSM:2 of the following: immobile body/stupor, excessive motor activity that is purposeless and unrelated to outside stimuli,
extreme negativism (resistance to being moved/follow instructions)/mutism, assumption of bizarre postures, Echolalia or echopraxia.
Undifferentiated type- meets the usual criteria for schizophrenia in varying combinations and does not clearly fit into one of the previous
types.
Residual type- used for people who have suffered at least one episode of schizophrenia but do not show any prominent positive
symptoms (ie hallucinations, delusions or disorganized speech/behaviour. Contains mostly negative symptoms.
Other psychotic disorders
Schizoaffective disorder-an illness during which, at some time, there is either a Major Depressive Episode, a Manic Episode, or a Mixed
episode that co-occurs with symptoms of Schizophrenia (delusions, hallucinations, disorganized, or negative symptoms). During the
illness, there must be a period of at least 2 weeks where delusions have been present without mood symptoms, but the mood symptoms are
present for a substantial proportion of the total illness time
-unclear whether this is a variant of schizophrenia or a mood disorder.
-long term (10 year) outcome is better for schizoaffective patients than for schizophrenic
Schizophreniform disorder- symptoms of schizophrenia; an episode of the disorder (including the prodromal, active and residual phases)
that lasts at least 1 month but less than 6 months, so do not warrant a diagnosis of schizophrenia. could be early onset of later
schizophrenia
Selusional disorder- nonbizarre dilusions (ie: involving situations that could occur in real life such as being followed/poisoned) that last
at least 1 month, no evidence of full-blown schizophrenia, apart from the delusion functioning is not markedly impaired; neither is
behaviour obviously odd/bizarre.
Brief psychotic disorder-presence of one or more of: delusions, hallucinations, disorganized speech/behaviour/catatonic behaviour.
Episode lasts at least one day, less than one munth with an eventual return to normal functioning. Diagnosis of Mood disorder with
psychotic features: schizoaffective disorder or schizophrenia is ruled out.
Shared psychotic disorder-aka folie a deux-a delusion that develops in someone who has a very close relationship with someone who is
delusion. The delusion is similar in content to that of the person who established the delusion.
Causes of Schizophrenia
Genetic-10% likely prevalence of schizophrenia in the first-degree relatives (parents, siblings, children). 3% for second degree relatives
(half-siblings, aunts, uncles, cousins). 50% prevalence for identical twins.
Twin studies- the most famous concordance rate for schizophrenia is in the Genain quadruplets (monozygotic)- all were concordant for
schizophrenia, but discordant in severity of illness. Most severe was the sister born last. Third born was the highest functioning.
Eventually went into remission. Higher concordance among identical siblings (monozygotic)
-not exclusively a genetic disorder however, because the concordance rate for identical twins is only 50%, not 100%.
-twin studies show that environment also plays a role
Age-correlated incidence rate
-17.4% for the offspring of nonschizophrenic monozygotic twins- very similar to the rate of di-zygotic twins
Twin and Adoption studies
-Heston’s study began by identifying mothers with schizophrenia and then tracing what had happened to their adopted- away offspring.
An alternative approach involves locating adult patients with schizophrenia who were adopted early in life and then looking at rates of
schizophrenia in their biological and adoptive relatives.
-Finland adoption study: One measure of the family environment that the researchers looked at was communication deviance ( Wahlberg
& Wynne, 1997). Communication deviance is a measure of how understandable and “ easy to follow” the speech of a family member is.
Vague, confusing, and unclear communication reflects high communication deviance. What Wahlberg and colleagues found was that it
was the combination of genetic risk and high communica-tion deviance in the adopted families that was problem-atic. Children who were
at genetic risk and who lived in families where there was high communication deviance showed high levels of thought disorder at the time
of the follow- up.
-children with a genetic risk for schizophrenia are more likely to develop the disorder if they are raised in dysfunctional family
environments: suggest that our genetic makeup may control how sensitive we are to certain aspects of our environments.
Molecular genetics
-linkage analysis: using DNA markers, researchers can locate a few important genes associated with observable traits (ie colour
blindness)- they are looking to see if something like schizophrenia co-occurs with any known DNA marker traits.
-candidate genes-genes known to be involved in some of the processes thought to be aberrant in schizophrenia (ie genes implicated in
dopamine metabolism)
Prenatal issues
-because more people in the northern hemisphere with schizophrena are born between January and March (than would be expected by
chance)- Kraepelin suggested that perhaps some seasonal factor (ie a virus) could cause schizophrenia during prenatal/perinatal
development.
-similarly, 1957 there was a flu epidemic in finland-Researchers found elevated rates of schizophrenia of kids born to mothers
who had been in their 2nd trimester of pregnancy during the epidemic.
-Rheus (Rh) incompatibility (when an Rh negative mother carries an Rh positive fetus) is also associated with increased risk for
schizophrenia. Possibly because of hypoxia
-research also shows that complicated pregnancies/deliveries are associated with schizophrenia
Development
-studies viewing home videos found that preschizophrenic children showed more motor abnormali-ties including unusual hand
movements than their healthy siblings; they also showed less positive facial emotion and more negative facial emotion. In some instances
these dif-ferences were apparent by age 2. (Walker)
-endophenotypes- discrete, measurable traits thought to be linked to specific genes that might be important in schizophrenia.
Biological aspects