MBIO 1010 Chapter Notes - Chapter 8: Tissue Tropism, Endocytosis, Lytic Cycle
6 Dec 2016
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Obligate intracellular pathogens: reproduce only inside of living cells, lack independent metabolism. They rely on the host: have nucleic acid and proteins, can go from one cell to another to another to another. Composed of at least 2 parts: nucleic acid genome (dna or rna) and a protein coat (capsid) They can have dna or rna but not both at the same time. Some viruses have an envelope- layer of lipid surrounding the nucleocapsid. Can have an envelope, but doesn"t have to have one to survive. Smallest is 3. 6 kb for some ssrna viruses (3 genes: largest is 150 kb for some dsdna viruses (over 100 genes) Allows transfer of viral genome between host cells: mae of identical polypeptides- protomers. Textbook does not use the word promoters it says capsomeres: nucleic acid genome coiled inside, the subunits of the helical capsid is the capsomeres that attach on to the virus. Tobacco mosaic virus capsid made of about 2100 identical protomers.
