BIOL359 Chapter Notes - Chapter 5: Gene Duplication, Mutation Rate, Dna Mismatch Repair

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Janice wong: meiosis reshuffles existing alleles into new combinations, mutation is the only process that creates completely new alleles and new genes, mutation is the ultimate source of genetic variation. Point mutaitons: point mutation: create a change in a single base pair in dna. They occur when errors in dna replication or repair are not fixed properly: 1. Random errors in the repair of sites damaged by chemical mutagens or high- energy radiation: transition: a type of point mutation. If either type of base substitution occurs in the coding region of a gene, the mutation changes the codon read by the protein, called rnap, that synthesizes rna from the. Mutation rates: loss-of-function mutations: also known as knock out mutations. Changes in dna that inactivate a gene, leading to a complete lack of gene product. Human dwarfism and haemophilia a (impaired blood clotting: natural selection had led to a single, common mutation rate.

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