CHEM237 Chapter Notes - Chapter 11: Coagulation, Serine Protease, Transition Metal

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Document Summary

Some rna molecules can catalyse some reaction = ribozymes. Highly stereospecific: can distinguish between two enantiomers or other isomers. Reactions occur in asymmetric pocket of the enzyme called the active site, which consists of: binding site where substrate comes into contact with, provides binding energy and specificity, catalytic side residues responsible for catalysis. Noncovalent bonds involved in binding (van der waals, electrostatic, hydrogen bonding, hydrophobic) Prochiral differentiation is having two of the same molecules attached to the primary carbon but one of them can be modified but the other cannot. Cofactors are usually metals, coenzyme organic-like molecule. Higher the hill the less stable the transition state is and the slower the reaction will be. There are many different catalytic methods used by enzymes: acid-base catalysis proton transfer between enzyme and substrate. Some reactions have both general base and general acid catalysis concerted acid-base catalyzed reaction.