CHEM266 Chapter Notes - Chapter 11: Stereospecificity, Reagent, Allyl Group
9 Nov 2016
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Chapter 11 notes substitution-elimination and discerning the differences. Carbons bonded adjacent to a specific functional group are labeled outward using greek letters (this can also apply to the hydrogens bonded to labeled carbons) Elimination reaction: removal or elimination of substituents of the molecule to form an alkene in one- or two-step mechanism, often called -elimination because occurs between the and carbons. Leaving group (lg): must be able to leave as a relatively stable, weakly basic molecule or ion. Unimolecular (e1): rate of reaction is only dependent on [substrate], reaction rate is first-order. Bimolecular (e2): rate of reaction is dependent on [base] and [substrate], reaction rate is second-order. Regiochemistry: reaction that can occur with different regions on a molecule to produce different products and regiochemistry is the difference in reactivity of the sites. Regioselective reaction: more than one reactive site then a regioselective reaction can occur, producing one major product when many possible products are possible.
