CHEM266 Chapter Notes - Chapter 14: Organolithium Reagent, Grignard Reaction, Carbonyl Group
23 Nov 2016
School
Department
Course
Professor
Document Summary
Regiochemistry: reaction that can occur with different regions on a molecule to produce different products and regiochemistry is the difference in reactivity of the sites. Regioselective reaction: more than one reactive site then a regioselective reaction can occur, producing one major product when many possible products are possible. Stereoselective reaction: a single reactant can produce two or more stereoisomeric products and one of these products is preferred over the other. Stereospecific reaction: single reactant can produce two or more stereoisomeric products and one of these products is exclusively formed over the other(s) Zaitsev"s rule: when two or more alkenes can be produced in an elimination reaction, the thermodynamically most stable alkene (the alkene that has the most alkyl groups attached to the alkene. Hyperconjugation: stability of a carbocation increases as the number of alkyl groups attached to the electron- deficient carbon increases. Adjacent lone pairs: atoms adjacent that have lone pairs (n, o, s, halogens) will stabilize carbocations through resonance.
