KIN217 Chapter Notes - Chapter 9: Mutation, Valine, Anemia
Document Summary
Haemoglobin is a component of rbcs; carries oxygen from lungs to tissue and contributes to transport of carbon dioxide and h ions back to lungs. Allostery is not a property limited to enzymes. Haemoglobin is the first allosteric protein known in atomic detail. Myglobin is located in muscle; facilitates the diffusion of oxygen to cellular sites that require oxygen and provide a reserve supply of oxygen in times of need, although the exact role is uncertain. Binding of oxygen to hemoglobin isolated from rbcs displays sigmoidal behaviour, which is characteristic of cooperation b/w subunits. Strongly binds oxygen in one area and easily releases it in another. Oxygen must be transported in blood from the lungs where po2 is high (100 torr) to the tissues where po2 is much lower (20 torr) Hemoglobin releases 62% of its oxygen to the tissues; myoglobin only releases 7% It is the cooperativity b/w o2 binding sites of hemoglobin that allows for efficient oxygen transport.