KIN217 Chapter Notes - Chapter 19: Isocitrate Dehydrogenase, Succinyl-Coa, Oxidative Decarboxylation

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The citric acid cycle: 2 parts , oxidize carbon atoms to co2. Involves joining 2c acetyl to 6c oxaloacetate: followed by oxidative carboxylation (back to 4c, 2co2 and 2 nadh produced, regenerate oxaloactate. Stage 1: citrate isomerization: acontinase, move hydroxy from central carbon close to terminal c (completed by dehydration/re, set up molecule for oxidative decarboxylation. Stage 1 : oxidative decarboxylation of isocitrate to alpha ketoglutarate. Isocitrate dehydrogenase: releases electrons by converting hydroxy to carbonyl (electron captured by nad+, Nadh: oxalosuccinate is unstable (central carboxy group leaves as co2) Stage 1: succinyl coa formed from alpha keto: alpha keto dehydrog complex, homologous to pdh complex (phd pyruvate (3c) + nad+ to acetyl coa (2c) + co2 + Nadh: oxidative decarboxylation via interaction of 3 subunits of complex (electrons eventually captured by nadh, thioester formed in process has high energy transfer potential)

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