PSYCH261 Chapter Notes - Chapter 4: Basal Forebrain, Fluoxetine, Atropine

• School: University of Waterloo
• Department: Psychology
• Course: PSYCH261
• Professor: Daniel Smilek

Document Summary

Routes of administration: lab animals-most common is injection-drugs is dissolved in liquid and injected through a hypodermic needle. Intraperitoneal (ip) injection: injection into the peritoneal cavity-space that surrounds stomach, intestines, liver and other abdominal organs: most common for administering drugs. Intrarectal administration: into rectum: most commonly used to administer drugs that might upset stomach. Inhalation: administration of vaporous substance into lungs: route from lungs to brain is short and have rapid effects, topical administration: directly on skin or mucous membrane, natural or artificial steroid can be administered this was (ex. Nicotine: also on the mucous membrane in the nasal passage. Intracerebral administration: directly into brain: crosses blood-brain barrier. Intracerebroventricular (icv): injected into one of the cerebral ventricles: passes blood-brain barrier, drug is absorbed into brain tissue, cocaine. Important factor that determines the rate at which a drug in bloodstream reaches sites of action within the brain is lipid solubility: blood-brain barrier is barrier only for water-soluble molecules.