PSYC 304 Chapter Notes - Chapter 9: Subventricular Zone, Intellectual Disability, Bromodeoxyuridine
Document Summary
18 days past conception, the neural plate forms from the ectoderm. Most of the proliferation occurs right along the central hollow--the ventricular zone. Cells created at ventricular zone then migrate to appropriate target locations--via radial (parallel or along a radius of the tube"s hollow), or tangential (along the length of the tube or clockwise/counterclockwise relative to the hollow). Cell migration involve leading processes (feelers, where the one going in the right direction elongates while the others retract), and then are pulled along (somal translocation). Many developing neural cells migrate in an inside-out pattern (inner layer, then outer layer, then outer layer) (rakic) Once migrated, they must align with other neurons in their target destination (aggregation)--by cell adhesion molecules (cams) and gap junctions. Once it migrates and agregates, its processes grow substantially. Growth cones: amoebalike structure at the growing tip of a process. Sperry: chemoaffinity hypothesis (zeroing in on a chemical signal).
