HSS 3305 Chapter Notes - Chapter 4: Innate Immune System, Vascular Permeability, Exudate

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Inflammatory reaction part of innate immune response to agents that cause cell injury. Nonsepcific response to any agent that causes cell injury (physical, chemical, microbiologic: pathogen associated molecular patterns (pamp), damage associated molecule patterns (damp), pattern or pathogen recognition receptors (prr) Local inflammatory effects signs include heat, redness, tenderness, swelling, and pain: capillary dilatation increased blood flow causing increased warmth and redness, tenderness and pain caused by irritation of sensory nerve endings from swelling and. Mild inflammatory process self-limiting, subsides with tissue resolution (return to normal) Acute inflammation: occurs immediate after injury and lasts for 24-48hrs. Involves active phagocytic neutrophils, platelets that adhere to collagen at site of blood vessel injury and mediate the coagulation of blood to control hemorrhage related to tissue trauma. Involves mast cells found in tissue, often associated with blood vessels: presence of neutrophils and macrophages. Chemical mediators of inflammation chemical agents that are formed and released when tissue is damaged to intensify the inflammatory process.

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