BIO206H5 Chapter Notes - Chapter chapter 4: Van Der Waals Force, Hydrogen Bond, Protein Structure

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Protein is made up of a long chain of amino acids held together by peptide bonds. Long polypeptide chains are very exible since peptide bonds allow free rotation of the atoms they join. However, shapes that they can make are constrained by many sets of weak non- covalent bonds. Most important ones that help proteins fold and keep their shape is hydrogen bonds, van der waals forces and electrostatic attractions. It takes many non-covalent bonds to hold 2 regions of a polypeptide together since they are weaker than non-covalent bonds. Hydrophobic amino acid molecules (so the ones with non polar side chains) tend to be forced together to minimize their disruptive effect on the hydrogen-bonded water molecules around them. They it is important that when a protein is folding, that the non polar side chains go in the interior, while polar side chains tend to arrange them selves near the outside of the folded protein.

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