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Textbook Notes for BIO304H5 at University of Toronto Mississauga (UTM)

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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Chapter Notes - Chapter 1: G Protein–Coupled Receptor, Ion Channel, Cell Membrane

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Excitable cells (neurons, muscle cells, receptor cells) can generate electrical signals. They use ion channel receptors to convert other signals into e
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Chapter Notes - Chapter 1: Myelin, Axon Terminal, Action Potential

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Neuron has a cell body (soma) where the nucleus is. On the other end, the axon branches into axon terminals to send signals. The axon terminals are loc
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Chapter Notes - Chapter 7: Voltage Clamp, Positive Feedback

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H&h also used the voltage clamp to observe how holding voltage affects inactivation of the na+current, and hence navchannels: recall that only navchann
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Chapter Notes - Chapter 8: Bert Sakmann, Patch Clamp, Voltage Clamp

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How do macroscopic currents relate to single channel currents: erwin neherand bert sakmann , invented the patch clamp technique, permitsrecording of si
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Chapter 6: 304 7

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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Chapter Notes - Chapter 5: Circuit Diagram, Alan Lloyd Hodgkin, Andrew Huxley

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Vmat rest can be defined by the ghk equation: the k+gradient and ekwins because it has the larger conductance (gk>>gna), the cell membrane is packed wi
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Chapter Notes - Chapter 3: Alessandro Volta, Luigi Galvani, Connectome

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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Chapter Notes - Chapter 2: Exocytosis, Reticular Theory, Potassium Dichromate

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Regression on graded vs. action potentials: gradedpotentials fizzle out over time, gradedpotentials can be excitatory(depolarizing) or inhibitory(hyper
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Chapter Notes - Chapter 4: Resting Potential, Neuroglia, Cell Membrane

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In all living cells (including bacteria), pumps and exchanges ensure that : k+is more abundant inside than outside, na+is more abundant outside than in
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Chapter Notes - Chapter 6: Apoptosis, Exocytosis, Muscle Contraction

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2+needs to be removed from the cytoplasm quickly: cytoplasmic chelators bind free ca2+to remove it from solution, pumpsand exchangersextrude ca2+from t
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Chapter Notes - Chapter 2: Neuron, Retina, Ganglion Cell

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And so what is a nerve cell: a cell that can generate electrical impulses? (e. g. action potentials, even bacteria and plant cells can generate electri
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Chapter Notes - Chapter 9: Depolarization

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