BIO304H5 Chapter Notes - Chapter 4: Resting Potential, Neuroglia, Cell Membrane

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8 Feb 2019
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In all living cells (including bacteria), pumps and exchanges ensure that : k+is more abundant inside than outside, na+is more abundant outside than inside, ca2+is very low inside (toxic: precipitates proteins and organic/inorganic anions!!, cl-is variable. Sea water animals have more than double the ion concentrations compared to fresh water and land animals: roughly the same ratios in/out however, with k+more abundant inside and na+more abundant outside. Thought experiment: the ion shown (purple) is positively charged, its concentration is higher inside compared to outside, the membrane voltage is negative inside compared to outside (a. k. a. positive outside) Regression on membrane voltage (vm): where does it take place, cell membrane = capacitor, what charges the voltage/capacitor, different ion gradients, which ions control vm, those that can flow across the cell membrane. So, we"ve noted that ions gradients can influence vm(slides 11, 13 and: next, we"ll look at how different ions compete to control vmto set.

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