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ENV332H5 (10)
Chapter 9

ENV232H5 Chapter 9 notes

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University of Toronto Mississauga
Patricia Houston

Chapter 9: Environmental Endocrine Disruption: • Some chemicals unintentionally interfere with hormone function in animals and in some cases in humans. • A wave of interdisciplinary research over the past few years has been demonstrated that chemicals in our environment can interfere with endocrine function. • In adults the endocrine system exhibits the ability to recover from fairly significant perturbations, in the fetus even minor change in hormone levels can result in lifelong effects. • Historical background: • A study in laboratory animals have demonstrated that estrogenic properties of a number of industrial chemicals including bisphenol A, now widely used in plastics, resins and dental sealants. • Hormonally active chemicals are widely used for beneficial medical purposes, but adverse effects also occur. • Diethylstilbestrol (DES) daughters have an increased risk of reproductive and immunological abnormalities, while sons are at risk of genital anomalies and abnormal spermatogenesis. • Examples of DES indicate that fetus rather than the adult may be most at risk from adverse effects of hormonal disruption. • Mechanisms of Action and Fetal Vulnerability: • Some pesticides and other industrial checmicals can directly bind to or block hormone receptors, thereby initiating or blocking receptor-activated gene transcription—the production of protentis from genetic information. • Other environmental chemical act indirectly on hormonal balance by altering hormone production, hormone transport on hormonal balance by altering hormone production, hormone transport on binding proteins, receptor numbers on target organs or hormone metabolism. • Polychliroinated biphenyls (PCBs) interfere with thyroid function by a variety of mechanism, including increased metabolism of the thyroid hormone T inte4.,re with T4delivery to the developing brain by displacement from the carrier protein and interfere with the conversion of T to the active form of thyroid hormone 4 known as T 3. • During development, the fetus is more sensitive to hormonal fluctuation. • Low level exposure to hormones or toxicants may result in permanent physiological changes not seen in adults exposed at similar levels. • Subtle hypothyroidism during fetal and neonatal life causes disruption of neurotransmitters, nerve growth factors, nerve cell growth and normal energy production in the developing brain, altering cognitive and neuromotor development. • Potential Health implications: • Reported abnormalities in labortoary animals and wildlife exposed to endocrine- disrupting chemicals include feminization of males, abnormal sexual behaviour, birth defects, altered sex ratio, lower sperm density, decreased testis size, altered time to puberty, cancers of the mammary glands or testis, reproductive failure, and thyroid dysfunction. • Epidemiological studies have found associations between exposure to specific pesticides or industrial chemicals and thyroid stimulating hormone, testosterone and prolacting levels in adults. • Some of these studies have also found signifincant association with other relevant endpoints including diminished sperm quality, impaired sexual function, and testicular cancer. • Numerous studies have found associations between occupational solvent or pesticide exposure and subfertility or adverse effects on offspring but its not clear i
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