CHAPTER 21: MORE ABOUT AMINES • HETEROCYCLIC COMPOUNDS
Amines – compounds in which one or more of the hydrogens of ammonia (NH ) have b3en
replaced by an alkyl group.
The lone-pair electros of the nitrogen atom cause amines to react as bases, sharing the lone
pair with a proton, and as nucleophiles, sharing the lone pair with an atom other than a
Some amines are heterocyclic compounds (or heterocycles) – cyclic compounds in which
one or more of the atoms of the ring are heteroatoms.
21.1 More about the Acid-Base Properties of Amines
Amines have very high pK valaes.
21.3 Amines React as Bases and as Nucleophiles
The lone pair on the nitrogen of an amine causes it to be nucleophilic as well as basic.
10.8 Amines Do Not Undergo Substitution or Elimination Reactions
The weaker the acid, the stronger its conjugate base and the poorer the base is as a leaving
The leaving group of an amine ( NH ) 2s such a strong base that amines cannot undergo
substitution or elimination reactions. The lone pair on the nitrogen atom a