LECTURE 4: CHEMICAL HAZARDS AND HUMAN HEALTH

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Department
Environmental Science
Course
EESA10H3
Professor
Jovan Stefanovic
Semester
Fall

Description
Lecture 4 Chemical Hazards and Human HealthChemical Hazardsspread everywhere in all mediums Endocrine disruptors Chemical body burdens Both are interconnected with each other Endocrine problems can be a body burden and vice versaData mostly from animal studies not much from human exposure Animals have similar physiology to humans and scientists are working on it very hard to get better answers Endocrine disruptors organs that produce hormones which help in coordinate the body functions are disrupted in some way or the other 1 Direct effectsBind to hormone receptorsAlter the appearance of some genes which can alter the appearance Changes in the level of produced proteins2 Indirect effectsAltering hormone productionAltering hormone transportAltering hormone metabolismFetus more sensitive than adultsDES diethylstilbesteol Synthetic estrogen used by physicians to prevent spontaneous abortion 19481971 Administered for early pregnancy until 35 weeks1million women took it between 19601970 Daughters whose mothers took DES have increased incidents of Reproductive organ dysfunction Abnormal pregnancies Reduction in fertility Immune system disorders Adenocarcinoma Some type of carcinoma Mothers didnt suffer as much as the kids didEndocrine disruptorsHealth Implications Feminization of males Abnormal sexual behavior Birth defects Altered time to puberty Cancer of mammary glands or testis Thyroid dysfunction especially by PCBsEndocrine disruptorsneurobehavioral effects
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