HLTB21H3 Chapter Notes -Leprosy, Molokai, Macrophage
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2 forms of leoprosy
1. tuberculoid: bacteria lies in skin nodules (organs affected: skin, nerves)
2. lepromatous: lies in macrophages (multiple organs involved, eye problems, heart
1. What does the pioneering work of Moller - Christensen show about the diagnosis of Hansen’s
disease in the Middle Ages?
2. Give an overview of the history of Hansen’s disaease for Hawaii and Luisiana
Answer: @Hawaii, brought by chinese workers, first case in 1945, put to molokai.
Environment was bad. 70 lepromatous
@Louisiana, Arcadians introduced disease in 1755
3. What is the nature of the relationship between Hansen’s Disease and Tuberculosis?
Answer: If one person has TB they have a lesser chance of getting Hansen’s disease (but not
the other way around Leprosy ruins the immune system). The 2 bacteria are in the same genome,
M.Leprae takes longer to divide, only grow in humans, mice, armadillo.
4. Discuss the importance of Robert Koch’s work
Answer: German physician, discovered a vaccine for TB, but not very effective. Also found
bacteria for Cholera.
NOTES ON TB AND HANSENS DISEASE Feb 5, 2010