HLTB21H3 Chapter 7: Chapters 7, 8, 9

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14 Dec 2010
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Origin-old world disease and an indiscriminate disease, 10000bc first agricultural settlements in ne africa and spread to. India by means of ancient egyptian merchants, earliest evidence on mummies (1570-1085bc) pharaoh ramses v died. 1122bc in china mentioned in ancient text of india, 100ad plague of antonine, europe: frequent epidemic during middle ages, 16th century became a serious disease in england and europe. Etiology-virus: genus orthopoxvirus(also includes: monkeypox, cowpox, camelpox virus etc. Clinical manifestation-acute onset-fever, malaise, rigors, vomiting, headache, backache, and occasionally delirium. Epidemiology-18th century-60 million europeans, case fatality rate varied from 20-60%, 1/3 of survivor became blind, acquired immunity disease of childhood, epidemic every 5-15 years. Variolation led to the practice of vaccination, controversy over who started vaccination, he planned the experiments, 1796. Sp canada-1796 dr. john clinch forwarded a letter to dr. edward jenner in gloucestershire requesting info about using cowpox pustule matter; -1799 vaccinating people in newfoundland. Late 19th century realized that subsequent revaccination was necessary.

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