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Chapter 12

Chapter 12 Syphilis.docx

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Aqdas QasemPlagues and Peoples Syphilis Text Chpt12 CR 10251032 20101024Textbook Chapter 12 The Great Pox Syphilis 255 Tuskegee Syphilis Study 1932 US Public Health Service enlisted 399 poor black males in Macon County Alabama all with latent syphilis They were offered financial incentives ex free burial if agreed to autopsy free physical exams and aspirin when needed Men and family not told they had syphilis They were deprived of treatment for their syphilis 28 men died of syphilis 100 others died of related complications 40 wives infected and 19 children Designed to document the natural history of syphilis but went terribly wrongA Look Back From 1493 onward swept over Europe and the rest of the world 1494 King Charles Vlll of France invades Italy During the attack his troops fell ill with the Greart Pox and this forced their withdrawal Following this the disease spread throughout Europe and spread to the rest of the world Theory Brought to Naples by the Spanish troops sent to support against attack from King Charles Vlll The French called this pox the disease of Naples blaming the Italians for it and the Italians called it the French Disease In England called it the Spanish Disease Symptoms fevers open sores disfiguring scars disabling pains in the joints and gruesome deathsTwo theories of how Charles VIIs men caught the disease Columbian and preColumbianantiColumbian theory Columbian Theory Introduced to Europe from the New WorldColumbian TheoryWritten recordSkeletal remains from the AmericasThe pattern of spread of the diseasepreColumbian TheoryAntiColumbian holds that syphilis was present in Europe before the discovery of the Americas by EuropeansUnitarian versus nonunitarian theoryMany populations of native Americans themselves were decimated by syphilis in the 16th century after the arrival of the Europeans Theories for the rapid outbreak of syphilis 1 kissing because that was the greeting in England shared drinks canker on lips misunderstood to be cold sore Tried Mercury for the treatment either applied directly to sores or taken in the form of a drink Treatment known as salivationSpirochete Discovered 260 Girolamo Fracastoro called disease syphilis after a fictitious shepherd named Syphilis who got it by cursing the gods Frit Schaudinn and Erich Hoffman identified slender spiralshaped bacterium a spirochete in the syphilitic chancres a dull red hard insensitive lesion that is the first manifestation of syphilis Baciteria Treponema pallidumCan be growin in lab animals such as rabbits and guinea pigs but humans are the only natural hostsTook so long to discover bacteria because syphilis was confused with gonorrhoea at the time The Disease Syphilis 262STDs such as syphilis were once known as venereal disease because Venereal refers to Roman goddess of LoveSyphilis also known as the great imitator The chancre stage is the earliest clinical sign of diseaseAfter initial infection a painless peasized ulcera chancreappears at the site of spirochete inoculationThe chancre is a local tissue reaction and can occur on the lips fingers or genitals At this stage the infection can be spread by kissing or touching a person with active lesions on the lips genitalia or breasts and through breast milkPage 1
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