NROB60H3 Chapter 4: Ch. 4 NROB60

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17 Dec 2011
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The frequency and pattern of action potentials constitute the code used by neurons to transfer info. from one location to another. And records voltage as it changes over time. First part of ap rising phase a rapid depolarization of the membrane, continues until vm reaches 40 mv peak. Overshoot, where inside of neuron is positively charged with respect to the outside. Falling phase rapid repolarization until membrane become more neg. than the resting potential. Undershoot (after hyper polarization) is the last part of falling phase until gradual restoration of resting potential. Chain of events of an ap: thumbtack enters skin, membrane of nerve fibers in skin is stretched, na+ permeable channels open and due to large conc. gradient and (-) cytosol na+ enters through channels. Na+ depolarizes the membrane, cytosol becomes less negative. If gp achieves critical level, membrane goes through ap. Critical level of depolarization that must be crossed is threshold.

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