NROC61H3 Chapter : Article Notes
Document Summary
Sharif alkatib: cytokines produce signals read by the brain to indicate a site of inflammation leading to a fever and sickness-behaviors, cns. Crh: paraventricular nucleus hypophyseal portal blood supply. Ap: argine vasopressin, stimulate the release of adrenocorticotropin (acth) from. Causes adrenal glands to release glucorticoids: modulated by serotonergic, cholinergic and catecholaminergic systems. Inflammatory response, cytokine expression, ic trafficking, immune cell maturation and differentiation. Low levels: shift from pro-inflammatory (increased interleukins) and tumor necrosis factor alpha to anti-inflammatory and increased interleukin receptor antagonists. Hypothalamic-pituitary-gonadal axis: higher risk for lupus, rheumatoid arthritis, and ms (in, mediation between the hpa and hpg so that the fetus is, estrogen r for alpha and beta important for thymus women) not rejected development, sns (catecholamines) Inhibit tnf, il-12 and interferon-gamma and inflammatory cytokines. Stimulate anti-inflammatory cytokines (il-10) and transforming growth factor beta. Inhibit cellular immunity (th1) and strengthen humoral response (th2) Local dealings with inflammation with substance p, crh and: pns, opiods vasoactive intestinal polypeptide.
