NROC61 - Medina article notes

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1 Feb 2012
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Ribot gradient: memories might be processed over time. Muller&pilzecker: consolidation - post-acquisition processes that stabilize mem ories. Newly formed memory undergoes a lingering process, becoming stronger and resili ent over time until it is insensitive to disruption. Newly learned material consolidates over time, memory trace is vulnerable to di sruption only for a limited period after training. The time course of consolidation of a memory trace varies depending on learning task parameters and on brain structure being analyzed. Property of ltm is its sensitivity to protein synthesis inhibitors. During memory formation, protein synthesis is req"d to transform newly learned info into stable synaptic modifications. Ltm reqs de novo protein synthesis around time of training/during first few hrs post-training. Cell assemblies work together to represent info in the brain. Need to look at temporal contributions of diff regions of brain involved in pro cessing a learned experience. In diff species, diff types of memory req multiple and distinct neural circuits.

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