Mood disorder: involve disabling disturbances in emotion from sadness of depression to the elation and irritability of mania. Depression: emotional state marked by great sadness and feelings of worthlessness and guilt. Symptoms: withdrawal from others and loss of sleep, appetite, sexual desire, and interest and pleasure in usual activities. Associated with other problems panic attacks, substance abuse, sexual dysfunction, and personality disorder. They may speak slowly, after long pauses, using few words, monotonous voice. They prefer to sit alone and remain silent. May neglect personal hygiene and appearance and make numerous complains of somatic symptoms with no apparent physical base. Children results in somatic complaints (headaches or stomach aches) Older adults (distractibility and complaints of memory loss) Some cross cultural variation because of difference in cultural standards of acceptable behaviour. Psychologizers: people who emphasize the psychological aspects of depression: 15% of patients in canada, more non western cultures express physical symptoms rather than psychological.