Textbook Notes (381,164)
CA (168,383)
UTSC (19,323)
Psychology (10,052)
PSYB32H3 (1,181)
Chapter 2

Chapter 2

17 Pages
138 Views

Department
Psychology
Course Code
PSYB32H3
Professor
Konstantine Zakzanis

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Twin Method: both monozygotic twins (identical; develop from a single fertilized egg; same sex) and dizygotic twins
(fraternal; develop from separate eggs and are on average only 50% alike genetically; can be same sex or opposite) are
compared
Diagnosed cases compared to other twin to see presence of disorder
When twins are similar diagnostically they are said to be concordant; concordance for disorder should be greater in
MZ pairs than DZ pairs if this happens than disorder said to be heritable
For child to get the disorder that the parents have, there doesnt have to be a genetic predisposition it may run in
families only because of the environment the child was raised
Equal environment assumption: environmental factors that are partial causes of concordance are equally influential for
MZ pairs and DZ pairs; assumption only applies to factors that are plausible environmental causes of
psychopathology; this assumption asserts that MZ pairs and DZ pairs have equivalent number of stressful life
experiences
3 factors as biasing heritability estimates: violation of the equal environments assumption, sex of the participants and
his or her age when the assessment took place
oOnly environmental factors contributed to exposure to events involving non-assaultive traumas
oBoth genetic and environmental factors contributed to exposure to assaultive traumas
oTherefore, genetic factors may determine the extent to which a person is likely to experience post-traumatic stress
after an assaultive trauma
Adoptees Method: study children who were adopted and reared apart of their parents with abnormal disorders
If there is a high frequency of panic disorders found in children reared apart from parents who also had panic
disorders, then there would be support for the theory that genetic predisposition figures in the disorder
[Molecular Genetics]
Tries to specify the particular gene or genes involves and the precise functions of these genes
Each cell consists of 46 chromosomes with thousands of genes per chromosome (our genetic material)
Allele: refers to any one of the several DNA coding that occupy the same position or location on a chromosome:
genotype is his or her set of alleles
Genetic polymorphism: refers to variability among members of the species; involves differences in the DNA sequence
that can manifest in very different forms among members in the same habitat; entails mutations in a chromosome that
can be induced or naturally occurring
Linkage analysis: method in molecular genetics that is used to study people; researches use it to study families in
which a disorder is heavily concentrated; they collect diagnostic info and blood samples from affected individuals and
their relatives and use the blood samples to study the inheritance pattern of characteristics whose genetics are fully
understood (genetic markers)
If occurrence of a form of psychopathology among relatives goes along wit the occurrence of another characteristic
whose genetics are known, it is concluded that the gene predisposing individuals to the psychopathology is on the
same chromosome in a similar location on that chromosome (i.e. it is linked) as the gene controlling the other
characteristic
Linkage analysis: mood disorders, OCD and schizophrenia
www.notesolution.com
Gene-environment interactions: notion that a disorder or related symptoms are joint product of a genetic vulnerability
and specific environmental experiences or conditions
[Neuroscience and Biochemistry in the nervous system]
Neurons have 4 major parts: cell body, several dendrites (short and think extensions), one or more axons of varying
lengths (usually only one long and thin axon extending considerable distance from the cell body) and a terminal
buttons on the many end braches of the axon
Nerve impulse: change in electric potential of the cell
oWhen neuron is stimulated at its cell body or dendrites a nerve impulse travels down the axon to the terminal ending.
Between the terminal ending and cell membrane of receiving neuron is a small gap called the synapse
oTerminal buton of each axon contains synaptic vesicles (small structures that allow a nerve NT); NT are chemical
substances that allow a nerve impulse to cross the synapse
oNerve impulses cause the synaptic vesicles to release molecules of their transmitter substances and these molecules
flood the synapse and diffuse toward the receiving or postsynaptic neuron cell membrane of the postsynaptic cell
contains proteins (receptor sites) that are configured so that specific NT can fit into them when NT fit into receptor
site a msg can be sent to postsynaptic cell
oWhat happens to postsynaptic neuron depends on its integrating thousands of similar msgs
Sometimes msgs are excitatory: leading to the creation of nerve impulse in the postsynaptic cell
Msgs is inhibitory: making postsynaptic less likely to fire nerve impulse
Returning back to normal state:
oNot all released NT has found its way to postsynaptic receptors- some broken down by enzymes and some pumped
back into the presynaptic cell through a process of reuptake
Norepinephrine: NT of the peripheral sympathetic nervous system is involved in producing states of high arousal and
therefore may be involved in anxiety disorders
Serotonin and dopamine are NT in the brain; serotonin involved in depression and dopamine in schizophrenia
GABA: inhibits some nerve impulses and may be involved in anxiety disorders
Maturational changes influence NT levels
oOnset of puberty results in decrease in serotonin and a decrease in dopamine activity in certain cortical areas
Disorder is caused y either too much or too little of a particular transmitter (i.e. mania- too much norepinephrine;
anxiety disorder- too little GABA)
Synthesis of NT (series of metabolic steps): amino acids enzymes catalyzes each reaction
oToo much or little of NT results form error in one of the metabolic pathways or from alterations in usual processes
by which transmitters deactivated after being released into the synapse (i.e. reuptake)
Failure to pump leftover NT back into presynaptic cell and then new nerve impulse causes further NT to be
released into synapse therefore postsynaptic cell has double the dose of NT therefore more likely to fire a
nerve impulse
Receptors are also a cause of psychopathologies
www.notesolution.com
oIf receptor on postsynaptic neuron were too numerous or too easily excited the result would be akin to having too
much transmitter released therefore more sites available with which the NT could interact, increasing the changes of
the postsynaptic neuron would be stimulated
Delusions and hallucinations of schizophrenia may result from an over abundance of dopamine receptors
[Biological Approaches to Treatment]
Prevention or treatment of mental disorders should be possible by altering bodily functioning; biological defect 
biological intervention
Use of Psychoactive drugs increasing;
otranquilizers (valium) effective in reducing tension associated with some anxiety disorders by stimulating GABA
neurons to inhibit other neural systems that create the physical symptoms of anxiety
oantidepressants (Prozac) increase neural transmission in neurons that use serotonin as a NT by inhibiting reuptake of
serotonin
oantipsychotic drug (Clozaril) used for treatment of schizophrenia; reduces the activity of neurons that use dopamine
as NT by blocking their receptors
ostimulants (Ritalin) used to treat children with attention deficit and hyperactivity disorder; these increase levels of
several NT that help children pay attention
drugs can act efficiently and often provide symptomatic improvement relatively quickly
oserotonin reuptake inhibitors described as having delayed onset; helps to treat depression
contemporary approaches to biological assessment: involves attempts to make inferences about the functioning of the
nervous system (neuropsychological assessment) or to see the actual structure and functioning of the brain and other
parts of the nervous system (MRI)
clinical scientist can believe in biological basis of mental problem but can recommend psychological intervention
effects of cognitive-behavioural theory (CBT) on OCD showed decreased metabolism in the right caudate nucleus
whereas, CBT in phobia resulted in decreased activity in limbic and paralimbic areas
different effects for different types of interventions
[Evaluating the Biological Paradigm]
reductionism: view that whatever is being studied can and should be reduced to its more basic elements or constituents
problems such as delusional beliefs and dysfunctional attitude may well be impossible to explain biologically, even
with detailed understanding of the behaviour of individual neurons
PSYCHOANALYTIC/PSYCHODYNAMIC PARADGM
developed by Sigmund Freud psychopathology results from unconscious conflicts in the individual
[Classical psychoanalytic theory] refers to original views of Freud; his theories encompassed both the structure of the
mind itself and the development and dynamics of personality
-Structure of the mind-
he divided the mind into 3 parts : id, ego and superego- metaphors for specific functions or energies
www.notesolution.com

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Description
Twin Method: both monozygotic twins (identical; develop from a single fertilized egg; same sex) and dizygotic twins (fraternal; develop from separate eggs and are on average only 50% alike genetically; can be same sex or opposite) are compared Diagnosed cases compared to other twin to see presence of disorder When twins are similar diagnostically they are said to be concordant; concordance for disorder should be greater in MZ pairs than DZ pairs if this happens than disorder said to be heritable For child to get the disorder that the parents have, there doesnt have to be a genetic predisposition it may run in families only because of the environment the child was raised Equal environment assumption: environmental factors that are partial causes of concordance are equally influential for MZ pairs and DZ pairs; assumption only applies to factors that are plausible environmental causes of psychopathology; this assumption asserts that MZ pairs and DZ pairs have equivalent number of stressful life experiences 3 factors as biasing heritability estimates: violation of the equal environments assumption, sex of the participants and his or her age when the assessment took place o Only environmental factors contributed to exposure to events involving non-assaultive traumas o Both genetic and environmental factors contributed to exposure to assaultive traumas o Therefore, genetic factors may determine the extent to which a person is likely to experience post-traumatic stress after an assaultive trauma Adoptees Method: study children who were adopted and reared apart of their parents with abnormal disorders If there is a high frequency of panic disorders found in children reared apart from parents who also had panic disorders, then there would be support for the theory that genetic predisposition figures in the disorder [Molecular Genetics] Tries to specify the particular gene or genes involves and the precise functions of these genes Each cell consists of 46 chromosomes with thousands of genes per chromosome (our genetic material) Allele: refers to any one of the several DNA coding that occupy the same position or location on a chromosome: genotype is his or her set of alleles Genetic polymorphism: refers to variability among members of the species; involves differences in the DNA sequence that can manifest in very different forms among members in the same habitat; entails mutations in a chromosome that can be induced or naturally occurring Linkage analysis: method in molecular genetics that is used to study people; researches use it to study families in which a disorder is heavily concentrated; they collect diagnostic info and blood samples from affected individuals and their relatives and use the blood samples to study the inheritance pattern of characteristics whose genetics are fully understood (genetic markers) If occurrence of a form of psychopathology among relatives goes along wit the occurrence of another characteristic whose genetics are known, it is concluded that the gene predisposing individuals to the psychopathology is on the same chromosome in a similar location on that chromosome (i.e. it is linked) as the gene controlling the other characteristic Linkage analysis: mood disorders, OCD and schizophrenia www.notesolution.com Gene-environment interactions: notion that a disorder or related symptoms are joint product of a genetic vulnerability and specific environmental experiences or conditions [Neuroscience and Biochemistry in the nervous system] Neurons have 4 major parts: cell body, several dendrites (short and think extensions), one or more axons of varying lengths (usually only one long and thin axon extending considerable distance from the cell body) and a terminal buttons on the many end braches of the axon Nerve impulse: change in electric potential of the cell o When neuron is stimulated at its cell body or dendrites a nerve impulse travels down the axon to the terminal ending. Between the terminal ending and cell membrane of receiving neuron is a small gap called the synapse o Terminal buton of each axon contains synaptic vesicles (small structures that allow a nerve NT); NT are chemical substances that allow a nerve impulse to cross the synapse o Nerve impulses cause the synaptic vesicles to release molecules of their transmitter substances and these molecules flood the synapse and diffuse toward the receiving or postsynaptic neuron cell membrane of the postsynaptic cell contains proteins (receptor sites) that are configured so that specific NT can fit into them when NT fit into receptor site a msg can be sent to postsynaptic cell o What happens to postsynaptic neuron depends on its integrating thousands of similar msgs Sometimes msgs are excitatory: leading to the creation of nerve impulse in the postsynaptic cell Msgs is inhibitory: making postsynaptic less likely to fire nerve impulse Returning back to normal state: o Not all released NT has found its way to postsynaptic receptors- some broken down by enzymes and some pumped back into the presynaptic cell through a process of reuptake Norepinephrine: NT of the peripheral sympathetic nervous system is involved in producing states of high arousal and therefore may be involved in anxiety disorders Serotonin and dopamine are NT in the brain; serotonin involved in depression and dopamine in schizophrenia GABA: inhibits some nerve impulses and may be involved in anxiety disorders Maturational changes influence NT levels o Onset of puberty results in decrease in serotonin and a decrease in dopamine activity in certain cortical areas Disorder is caused y either too much or too little of a particular transmitter (i.e. mania- too much norepinephrine; anxiety disorder- too little GABA) Synthesis of NT (series of metabolic steps): amino acids enzymes catalyzes each reaction o Too much or little of NT results form error in one of the metabolic pathways or from alterations in usual processes by which transmitters deactivated after being released into the synapse (i.e. reuptake) Failure to pump leftover NT back into presynaptic cell and then new nerve impulse causes further NT to be released into synapse therefore postsynaptic cell has double the dose of NT therefore more likely to fire a nerve impulse Receptors are also a cause of psychopathologies www.notesolution.com
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