PSYB65H3 Chapter 16: PSYB65 - Chapter 16 - Nov 15, 2010

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When neurons completely lose their ability to regulate their internal environment (homeostasis), swelling and membrane bursting occur. this bursting / lysis spills the contents of the neuron into the extracellular space, which results in the death of the neuron. Often associated with damage that occurs rapidly, e. g. mechanical damage to the neurons, events that cause disruption to ion channels, or the results of inflection. It can also follow damage that accumulates more slowly. Common causes: ischemia (disruption in blood flow that often results from a stroke/cerebrovascular accident) affect ion channels that are important for homeostasis in the neuron (e. g. reduce/terminate. failure to maintain homeostatic levels of sodium and potassium will disrupt the neuron"s ability to regulate calcium and water, and will have disastrous effects for the neuron. failure to regulate water accumulation of intracellular water neuron"s swelling and potentially breaking its membrane cover.

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