PSYC62H3 Chapter 2: Chapter 2
Document Summary
Factors that determine drugs effect concentration of the drug at its site of action rate of accumulation dose: quantity of drug administered at one time dosage: administration of drug per unit of time. Drugs and receptors pharmacodynamics biochemical and physiological effects of drugs and their mechanisms of action receptors. Very specific sites all throughout the body where the vast majority of drugs act. Site is comprised of very large molecules, usually proteins. When ligand binds to receptor, receptor becomes activated ligand. Biologically active chemicals of the body induce the effects of proteins at receptor sites. When it occupies receptor, it is a bound ligand www. notesolution. com. * compound"s affinity and efficacy are independent of each other; however, without affinity, efficacy is unlikely to be exhibited agonists. If compound is endogenous, it"s called a ligand. If compound is exogenous, it"s a drug indirect agonist. Drug enhances the amount of endogenous ligands available for receptor.
