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Chapter 11

chapter 11

4 Pages
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Department
Psychology
Course Code
PSYC62H3
Professor
Suzanne Erb

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Chapter 11 – Psychotomimetics, psychedelics, hallucinogens (pg 278- 287)
Dissociative anesthetics: Phencyclidine and ketamine
one of the most predominant effects of phencyclidine PCP & its analogue ketamine is
profound anesthesia.
Patient anesthetized with these drugs are awake but appear disconnected form their env’t
termed as dissociative anesthetic
With PCP the letal dose was approx 10 times the anesthetic dose
At appropriate dose PCP induce insensivity to pain while increasing BP & heart rate
Pharmacodynamics & psychological effects of PCP
CNS of PCP are quite complex & probably involve wide variety of NT sys
PCP ability to antagonize NMDA-type glutamate receptor activity also appear to be a
major factor in its ability to increase extracellular DA conc in the nucleus accumbens,
prefrontal cortex, and basal ganglia
PCP has shown to potentiate the effects of electrical stimulation of the brain
Some properties of PCP are similar to those of the mixed agonist-antagonist narcotics like
cyclazocine, which are generally viewed as kappa opioid receptor agonists
Behavioral and pharmacodynmaic measures in rats indicate that high doses of PCP can
enhance serotonergic activity by binding to 5-HT transporter and inhibiting 5-HT
reuptake
Electrophysiologically sensory impulses to the cortex appear to be grossly distorted by
PCP partivuarly those involved in proprioception
Behaviorally in humans low dose (1 to 5 mg)of PCP produce a drunken state or floaty
euphori with numbness in the hand and feet
Moderate dose (5 to 15mg) induce analgesia and anesthesia & excited confused
intoxication can develop
Large dose of PCP induce a very definite psychosis and in rare cases convulsions
Death is rsarely directly caused by PCP because of its moderately high therapeutic index
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Description
Chapter 11 Psychotomimetics, psychedelics, hallucinogens (pg 278- 287) Dissociative anesthetics: Phencyclidine and ketamine one of the most predominant effects of phencyclidine PCP & its analogue ketamine is profound anesthesia. Patient anesthetized with these drugs are awake but appear disconnected form their envt termed as dissociative anesthetic With PCP the letal dose was approx 10 times the anesthetic dose At appropriate dose PCP induce insensivity to pain while increasing BP & heart rate Pharmacodynamics & psychological effects of PCP CNS of PCP are quite complex & probably involve wide variety of NT sys PCP ability to antagonize NMDA-type glutamate receptor activity also appear to be a major factor in its ability to increase extracellular DA conc in the nucleus accumbens, prefrontal cortex, and basal ganglia PCP has shown to potentiate the effects of electrical stimulation of the brain Some properties of PCP are similar to those of the mixed agonist-antagonist narcotics like cyclazocine, which are generally viewed as kappa opioid receptor agonists Behavioral and pharmacodynmaic measures in rats indicate that high doses of PCP can enhance serotonergic activity by binding to 5-HT transporter and inhibiting 5-HT reuptake Electrophysiologically sensory impulses to the cortex appear to be grossly distorted by PCP partivuarly those involved in proprioception Behaviorally in humans low dose (1 to 5 mg)of PCP produce a drunken state or floaty euphori with numbness in the hand and feet Moderate dose (5 to 15mg) induce analgesia and anesthesia & excited confused intoxication can develop Large dose of PCP induce a very definite psychosis and in rare cases convulsions Death is rsarely directly caused by PCP because of its moderately high therapeutic index www.notesolution.com
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