PSYD35H3 Chapter Notes - Chapter 1: Opioid Antagonist, Pulmonary Vein, Drug Metabolism
Document Summary
Psyd35- psychopharmacology- a primer of drug action, 12th edition. (2010) What body does to drug; 4 processes: absorption, distribution, metabolism, elimination. These processes together determine bioavailability of drug (of how much administered reaches target) Understanding drug kinetics gives knowledge about dose, concentration at receptor, intensity of drug effect, and time course. Pharmacokinetics implies movement and time which are integral in distinguishing a drug from other related drugs. Sedative/ao drugs: lorazepam (24h long acting) vs triazolam (6-8h short acting) Drugs have: structural name (chemical structure in words); generic name; trade name (patent) Parenteral(non-gi): injected, inhaled (gas, vapour, particles in aerosol); skin, mucous membranes (nose, etc. ) Drug must be soluble to be effective able to dissolve, not destroyed by gastric acid, enter intestine, go through lining and then finally enter the blood stream. Oral drugs as liquid absorb more rapidly than tablet form. Prodrug: oral formulation has precursor, that undergoes chemical change (through metabolism)
