PSYD35H3 Chapter Notes - Chapter 13: Nmda Receptor, Ethyl Glucuronide, Cannabinoid Receptor
Document Summary
Psyd35- a primer of drug action, 12th edition. Second most widely used psychoactive substance in world (after caffeine) Ethyl alcohol is a two carbon molecule in liquors alcohol present in 40-50% concentration (proof= x2 conc. ) Soluble in water and fat diffusing easily across membranes. Rapidly and absorbed completed from gi time from last drink to max conc. Evenly distributed thought out all body bbb very permeable to alcohol. Fetal levels are same as host levels. 95% alcohol metabolized by ad (other 5% excreted unchanged) ~85% metabolism occurs in liver; 15% by gastric ad in stomach lining (decreasing bal by ~15%) Metabolism of alcohol by gastric ad= first pass metbolism. Women have 50% less gastric metabolism of alcohol because of lower ad enzyme (so bal is about 7% higher than males) Men have greater muscle: fat than women (fat has little blood); alcohol is more diluted in men.
