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Canada (161,878)
Psychology (9,695)
PSYB65H3 (479)
Ted Petit (185)
Chapter 16

Chapter 16 -Neuropsychology :Clinical and Expt Foundations

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Ted Petit

Chapter 16 Recovery of Function Contrary to what is believed the normal adult brain does produce new neurons and neural death is a normal part of brain development 16.1 Neural Degeneration, Regeneration, and Reorganization Autopsy- provides specific information about the life and health of an individual and why the individual die but also provides important insights about how various diseasesconditions affect the body and possible treatments that could be used Most neurological diseases occur because neurons or glia cells and few people suffer brain damage due to accidents important to look at acute and long term effects to provide proper treatment regimes Degeneration Frequent causes of brain damage stroke, tumours, and infection (kill cells and produce a lesion) Cells such as neurons die in one of two ways: (1) Necrosis (homicide) failure to maintain homeostasis within the neuron causes death of the neuron, always an abnormal event can be due to inability to produce ATP, changes in [ion], and damage to organelles Causes the cell to swell and the membrane of the cell and its organelles and vesicles to burst Lysis(bursting) spills contents of the neuron into the ECF = death of the neuron Often Associated with damage that occurs rapidly, i.e., mechanical damage (tumour, blow to the head), disruption to ion channels (ischemia, anoxia), or infections such as rabies But can also be associated with damage that occurs more slowly near stroke areas or because of neurodegenerative diseases Ischemia (disruption in blood flow after stroke or CVA) usually causes necrotic cell death Ischemia disrupts energy pathways which can affect ion channels important for homeostasis For example, ischemia may cause a reduction or termination of ATP synthesis which is needed for the Na+K+ pump to function, therefore the cell cannot maintain these ion levels following an AP Disruptions in Na+K+ pumps also causes disruptions of pumps that maintain Ca2+ and water levels in the neuron increased internal water levels can lead to swelling and potential bursting of the membrane influx of calcium allows release of neurotransmitters so disruptions in its regulation affects neurotransmitters www.notesolution.com
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