Textbook Notes (368,720)
Canada (162,105)
Psychology (9,696)
PSYC62H3 (313)
Chapter 3

Chapter 3

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Suzanne Erb

Chapter 3 PHARMACOKINETICS Pharmacokinetics -process involved in the movement of drugs within biological systems -looks at drug in respect to absorption, distribution, binding in tissues, metabolic alterations, and excretion from the body Drug Absorption In order for drug to reach site of action, it has to pass through several biological membranes Depends upon the drugs site of action and the route of administration (Ex: orally administered drugs have to pass through all the biological membranes whereas intravenous injections dont have to go through the biological membranes) Salt form of drug, particle size of the dosage form, and suspending agent used can affect the degree of absorption The greater the differential concentration of the molecules on the two sides, the more readily the drug will diffuse into the body Lipid solubility -capability of being dissolved in fat -most important factor in a drugs ability to pass through these membranes - as lipid solubility increases, the better absorption from the blood, the faster it gets to the brain to exert its psychoactive effects In order to dissolve in plasma and be effectively transported by bloodstream, drugs must also be somewhat soluble in water Oilwater partition coefficient -drug concentration in the oil divided by drug concentration in water - the higher the coefficient, the more easily drug can passively penetrate lipoidal membrane www.notesolution.com
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