Textbook Notes (363,233)
Canada (158,276)
Psychology (9,573)
PSYC62H3 (280)
Chapter 5

Chapter 5

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University of Toronto Scarborough
Suzanne Erb

Chapter 5 Neuroactive Ligands and the Nervous System Neurotransmitters, Neuromodulators, and Neurohormones Neurotransmitters -chemicals located in specific regions of neurons that are released under specific stimulation -act on specific receptors and induce short term changes in membrane potential Neurohormones -chemicals synthesized in one area of the nervous system and are released into circulation -travel to site that is distant from release site and produce effect on brain or body Neuromodulators -chemicals with characteristics of neurotransmitters and neurohormones -have no intrinsic activity on their own -modify responses of other transmitters pre-synaptically or post-synaptically -a chemical can act as a neuromodulator in one area of the nervous system and a neurotransmitter in another part -therefore, collectively known as neurotransmitters: -in order for a chemical to be designated as a neurotransmitter: o Should be found in presynaptic neurons o Enzymes necessary for synthesis must also be present o Should be a mechanism for terminating its action o Direct application to post synaptic neuron must be same as stimulation to pre synaptic neuron o When presynaptic neuron is stimulated, synaptic cleft should contain the NT o Drugs that interfere with synthesis or reaction should block the effects of presynaptic neuronal stimulation o Drugs blocking the actions of inactivating enzyme should prolong transmitters actions -a psychoactive drug can alter many processes such as: www.notesolution.com
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