Chapter all: Molecular Biology of the Cell

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1 Dec 2016
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BIO120H1 Full Course Notes
BIO120H1 Full Course Notes
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Maintenance of dna sequences: low mutation rates, bacteria - mutation rate - ~ 3 nucleotide changes per 1010 nucleotides per cell generation, humans - mutation rate - ~ 1 nucleotide change per 108 nucleotides per human generation, humans. 1 mutation/1010 nucleotides/ cell division: importance of low mutation rates, germ cells pass genetic information from one generation to the next. Low mutation rates necessary to maintain the species: somatic cells form the body of the organism high mutation rates leads to cancer. Dna templating mechanism by which parent dna strand acts the template for producing a complementary daughter strand. Dna polymerase nucleotide polymerizing enzyme involved in dna replication: dna replication fork. Dna replication is semi-conservative newly produced dsdna will have 1 newly synthesized strand and 1 parent strand. Replication fork y shaped structure that actively moves along the parental dna during replication it has a multi-enzyme complex which includes dna polymerase.

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