BIO120H1 Chapter Notes - Chapter 10: Macrophage, Endocytosis, Fetal Circulation
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BIO120H1 Full Course Notes
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A successful primary immune response serves 3 purposes: clears the infection, temporarily strengthens defenses to prevent reinfection, establishes long term immunological memory. Immunological memory ensures subsequent infections with same pathogen give faster, stronger secondary immune response: this memory response is produced by circulating antibody and by expanded clones of b cells and t ells formed during primary response. The purpose of vaccination is to produce a state of immunological memory against pathogen before the pathogen is encountered. Immune responses made in all secondary lymphoid tissues can terminate infection and give immunological memory. Many infectious diseases are seasonal more exposed in winter. Antibodies made against cold caught at the start of winter prevent reinfection with the same virus (protective immunity). A second cold during winter usually due to different cold virus. After first infection with cold virus, this residual antibody may be insufficient to stop reinfection by the same virus. Almost all plasma cells made in primary response live couple months.
