Pg 1178-1195.docx

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10 Apr 2012
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Pg. 1178-1195
The Extracellular Matrix of animal Connective Tissues
The Extracellular Matrix is made and oriented by the Cell Within it
Macromolecules that in the extracellular matrix are normally produced in the
extracellular
Fibroblast: are inside connective tissues
Connective tissue is divided into two main classes
1. Glycosaminoglycan polysaccharide (usually connected to proteins)
2. Fibrous protein: ex collagen
Glycosaminoglycan tissues embed fibrous protein
Glycosaminoglycan (GAG) Chains occupy Large Amounts of space and form Hydrated
Gel
Glycosaminoglycan: unbranched polysaccharide chains composed of
repeating sugar contains amino acid and is usually sulfated
The other sugar is usually uronic acid (glucuronic, iduronic)
GAGs are negatively charged
These polysaccharides are hard to fold and form large masses
Hyaluroman Acts as a Space Filler and Faciliator of Cell Migration During Tissue
Morphogenesis
Hyaluroman: simplest GAG
Repeating sequence of disaccharides
Important cell filler
Proteoglycans are Composed of GAG Chains Covalently Linked to a Core Protein
All proteoglycans are attached to GAG
Can be huge
Elastin Gives Tissues Their Elasticity
Elastic fibres: gives the tissues extra strength
Main component of elastic fibres is elastin (Hydrophobic protein)
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