BIO130H1 Chapter Notes - Chapter 5: Microscope Slide, Model Organism, Organism

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17 Jun 2016
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BIO130H1 Full Course Notes
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Cytoskeleton made of complex network of protein filaments: protein filaments: microtubules, microfilaments, intermediate filaments, function of protein filaments: Motion: very dynamic, cell can reorganize 3d form of its cytoskeleton. Microtubules: long, hollow protein cylinders, built from repeating structural units = tubulin dimers. Tubulin dimer: one -tubulin + one -tubulin protein bound by non-covalent interactions. Tubulin dimers always interact with each other via head-to-tail polarity. Arrangement of -tubulin and -tubulin proteins results in polarity in the microtubule: Get one end of filament different from other. Two ends have differing growth rates (one grows faster than other: b/c end of microtubule has different kinetic rate constants for addition/removal of tubulin dimers. This dynamic activity allows cell to control/modify structure of cytoskeleton: can disassemble and reassemble microtubules where they required. Cell recycles tubulin dimers through continuous assembly/disassembly of microtubules: dimers added to plus end, others are lost from minus end of same filament.

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