BIO220H1 Chapter 5: Chapter 5 chapter notes

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25 May 2011
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BIO220H1 Full Course Notes
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Chapter 5: chemical messengers (selected based on lecture) Classes of chemical messengers: paracrines chemicals that communicate with neighboring cells. E. g. histamine responsible for allergic rxns and inflammations. secreted to ecf and reach target cell by diffusion. includes growth factors proteins that stimulate proliferation and differentiation of. cytokines cells function like paracrines and hormones travel thru bloodstream. Peptides release from immune system functioning as body defense and: neurotransmitters. Post synaptic target cell: hormones chemicals release from endocrine glands into if whre they can diffuse to blood to target cells. Neurohormones release by special class of neurons called neurosecretory cells though similar mechanism to nt release. Adh or vasopressin which is synthesized by neurosecretory cells originating in hypothalamus. Adh located in posterior pituitary glands travels in blood to its target. Lipophilic hydrophobic lipid soluble and ready to cross plasma membrane e. g. steroids, Eicosanoids paracrines that is lipids and insoluble to water.

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