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BIO130H1 (167)
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Pg 779-783.docx

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Department
Biology
Course
BIO130H1
Professor
John Coleman
Semester
Winter

Description
Pg.779-783 Transport from the Trans Golgi Network to Lysosomes  Trans Golgi Network: sorts all the protein that passes through the Golgi apparatus Lysosomes are the principle sites of Intracellular Digestion  Lysosomes: membrane enclosed compartments filled with enzymes that control intracellular digestion  Ex. Proteases, nucleases, glycosidases, lipases, phospholipases and sulfatases  All are acid hydrolases  For optimal activity the enzymes are activated in an acidic environment (pH =4.0-5.0) inside the lysosome  Cytosol has a pH of 7.2  Unique membrane structure highly glycosylated to protect it from lysosomal proteases  ATP pump can be used to acidify the lysosome: Uses ATP to create ADP and H+ Lysosomes are Heterogeneous  Extremely diverse in shape and size  Found in all eukaryotic cells  Lysosomes are formed by late endosomes with material from both the plasma membrane and newly synt
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