CHM247H1 Chapter Notes - Chapter 11: Nucleophilic Substitution, Steric Effects, Tosyl
Document Summary
Reactions of alkyl halides: nucleophilic substitutions and eliminations: carbon-halogen bond in an alkyl halide is polar and the carbon atom is electron-poor. Second-order reaction: a reaction whose rate limiting step is bimolecular and whose kinetics are therefore dependent on the concentration of two reactants. 11. 2 the sn2 reaction: kinetics: referring to reaction rates. Sn2 reaction: a bimolecular nucleophilic substitution reaction: sn2 is short for substitution, nucleophilic, bimolecular. An essential feature of an sn2 mechanism is that it takes place in a single step without intermediates when the incoming nucleophile reacts with the alkyl halide or tosylate from a direction opposite the group that is displaced. The substrate: steric effects in the sn2: the first sn2 reaction variable to look at it the structure of the substrate. A hindered substrate should prevent easy approach of the nucleophile, making bond formation difficult. The nucleophile: the nature of the nucleophile has a major effect on the sn2 reaction.
